Description

H-Ser-Tyr-Amc Hydrate is a fluorogenic peptide substrate designed for the sensitive detection and quantification of specific protease activity. This compound matters as a critical research tool in enzymology and drug discovery, enabling precise biochemical assays. It is primarily needed by pharmaceutical R&D laboratories, academic biochemistry departments, and diagnostic kit manufacturers focused on protease-related pathways.

Application

• Biochemical Research: As a specific substrate for studying serine or other protease kinetics and inhibition.
• Drug Discovery Screening: High-throughput screening (HTS) assays to identify novel protease inhibitors for therapeutic development.
• Enzyme Characterization: Determining enzyme activity, specificity, and catalytic efficiency in purified systems.
• Diagnostic Development: A key component in developing fluorometric diagnostic tests for diseases with dysregulated protease activity.
• Cell Biology Studies: Probing intracellular protease function and signaling pathways in live-cell imaging applications.
• Quality Control: Used in biomanufacturing to monitor the presence and activity of specific proteases in biological products.

Basic Information

Item	Detail
Product Name	H-Ser-Tyr-Amc Hydrate
CAS No.	207735-67-9
Molecular Formula	C21H22N4O6 • xH2O
Molecular Weight	426.43 g/mol (anhydrous basis)
Synonyms	H-Ser-Tyr-AMC; Ser-Tyr-7-amido-4-methylcoumarin; L-Seryl-L-tyrosyl-7-amido-4-methylcoumarin; Ser-Tyr-AMC; Suc-Ser-Tyr-AMC (related); Protease Substrate VII; Fluorogenic Peptide Substrate for Protease; AMC-labeled Ser-Tyr dipeptide
EINECS	Contact for details

Quality Control

Our H-Ser-Tyr-Amc Hydrate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification, to ensure consistency and performance for critical research applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 8.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water
Functional Activity	Conforms to reference standard in fluorogenic assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.