Description

6-Mercaptopurine Hydrochloride is a hydrochloride salt derivative of the thiopurine class, offering enhanced stability and solubility for pharmaceutical development. This compound is a critical active pharmaceutical ingredient (API) and a key intermediate in the synthesis of chemotherapeutic agents. It is primarily required by pharmaceutical manufacturers and research institutions engaged in oncology drug development and metabolic pathway studies.

Application

• Oncology Drug Manufacturing: Serves as a key active pharmaceutical ingredient (API) in the formulation of chemotherapeutic medications for treating acute lymphoblastic leukemia (ALL) and other cancers.
• Pharmaceutical Intermediate: Used as a crucial building block in the synthesis of more complex thiopurine analogs and prodrugs.
• Biochemical Research: Employed in laboratory studies to investigate purine metabolism, enzyme inhibition (e.g., of thiopurine methyltransferase), and cellular apoptosis mechanisms.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, or NMR method development and validation.
• Immunosuppressive Therapy Development: Investigated for use in formulations aimed at managing autoimmune diseases and preventing organ transplant rejection.

Basic Information

Product Name	6-Mercaptopurine Hydrochloride
CAS No.	207729-57-5
Molecular Formula	C5H5N4S•HCl
Molecular Weight	188.64 g/mol (Free base: 152.18)
Synonyms	6-MP Hydrochloride; Mercaptopurine HCl; 1,7-Dihydro-6H-purine-6-thione hydrochloride; 6-Thiohypoxanthine hydrochloride; Purine-6-thiol hydrochloride; NSC-755; 6-Mercaptopurine monohydrochloride
EINECS	Contact for details

Quality Control

Our 6-Mercaptopurine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) documenting compliance with relevant standards are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.