Description

Dihydrofolic Acid Dihydrate 90 is a key biochemical intermediate in the folate metabolic pathway. This compound is essential for research and development in pharmaceutical synthesis, particularly in the study of antifolate drugs and enzyme inhibition. It serves as a critical precursor and reference standard for scientists in the life sciences and fine chemical industries. The product is supplied with a high level of purity, ensuring reliable and reproducible results for demanding applications.

Application

• Pharmaceutical Research & Development: Acts as a crucial intermediate in the synthesis and study of novel antifolate therapeutic agents targeting diseases like cancer and bacterial infections.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for dihydrofolate reductase (DHFR) activity assays and pathway analysis.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical and academic laboratories.
• Life Science Reagent: Employed in cell culture and microbiology research to investigate folate metabolism and nucleotide biosynthesis.
• Fine Chemical Synthesis: Utilized as a specialized building block for the custom synthesis of complex molecules in medicinal chemistry.

Basic Information

Item	Detail
Product Name	Dihydrofolic Acid Dihydrate 90
CAS No.	207226-40-2
Molecular Formula	C19H23N7O6 • 2H2O
Molecular Weight	473.45 g/mol (Anhydrous basis: 437.43)
Synonyms	7,8-Dihydrofolic Acid Dihydrate; DHFA Dihydrate; 7,8-Dihydropteroylglutamic Acid Dihydrate; NSC 113928 Dihydrate; (2S)-2-[[4-[[(2-Amino-7,8-dihydro-4-oxo-1H-pteridin-6-yl)methyl]amino]benzoyl]amino]pentanedioic Acid Dihydrate; Dihydrofolate Dihydrate; H2Folate Dihydrate
EINECS	Contact for details

Quality Control

Our Dihydrofolic Acid Dihydrate 90 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is kept sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 90.0%
Water Content (KF)	6.0% - 9.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Sparingly soluble in water; soluble in alkaline solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.