Description

2-C-Methyl-D-Erythritol 4-Phosphate (MEP) is a critical phosphorylated intermediate in the non-mevalonate (MEP/DOXP) pathway for isoprenoid biosynthesis. This compound matters significantly for research and development in metabolic engineering and antimicrobial drug discovery, as the MEP pathway is essential in many pathogenic bacteria and apicomplexan parasites but absent in humans. It is primarily needed by pharmaceutical researchers, agrochemical developers, and biotechnologists working on novel antibiotics, herbicides, and the production of high-value isoprenoids.

Application

• Biochemical Research: Essential substrate and reference standard for studying the enzymes of the non-mevalonate isoprenoid pathway (DXS, DXR, IspD, IspE, IspF).
• Drug Discovery: Target molecule for the development of novel antibacterial and antimalarial agents that inhibit the MEP pathway in pathogens like E. coli, Mycobacterium tuberculosis, and Plasmodium falciparum.
• Agrochemical Development: Investigation of herbicidal compounds that disrupt the essential plastidial isoprenoid synthesis in plants.
• Metabolic Engineering: Used in microbial cell factories to optimize and quantify flux through the MEP pathway for the bioproduction of terpenoids, carotenoids, and artemisinin.
• Enzyme Assay Development: Serves as a key component in high-throughput screening (HTS) assays to identify inhibitors of MEP pathway enzymes.
• Diagnostic Kit Manufacturing: Potential use as a calibrated component in kits for research into bacterial metabolism and antibiotic resistance mechanisms.

Basic Information

Product Name	2-C-Methyl-D-Erythritol 4-Phosphate (MEP)
CAS No.	206440-72-4
Molecular Formula	C5H13O8P
Molecular Weight	232.12 g/mol
Synonyms	MEP; 2-C-Methyl-D-erythritol 4-phosphate; 4-(Phosphonooxy)-2-C-methyl-D-erythritol; 1-Deoxy-D-xylulose 5-phosphate pathway intermediate; DOXP pathway intermediate; (2R,3S)-2-Methyl-3,4-dihydroxybutyl dihydrogen phosphate; 2-C-Methylerythritol 4-phosphate
EINECS	Contact for details

Quality Control

Our 2-C-Methyl-D-Erythritol 4-Phosphate is produced under stringent conditions to ensure high purity and batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and specific optical rotation measurement. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.