Description

3'--Amino-2',3'-Dideoxy-5'-o-Methoxytrityl-5-Methyluridine is a key protected nucleoside derivative used as a critical building block in oligonucleotide synthesis. This compound matters for its role in the development of antisense oligonucleotides, siRNA, and other therapeutic nucleic acid analogs, where it provides a modified backbone for enhanced stability and targeted functionality. It is primarily needed by pharmaceutical R&D departments, biotechnology companies, and CDMOs specializing in advanced nucleic acid chemistry and novel therapeutic modalities.

Application

• Oligonucleotide Synthesis: Serves as a vital phosphoramidite precursor for solid-phase synthesis of modified DNA/RNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) for therapeutic applications.
• siRNA and miRNA Synthesis: A key intermediate for constructing small interfering RNA (siRNA) and microRNA (miRNA) with improved nuclease resistance.
• Pharmaceutical Intermediates: Acts as a high-value building block in the synthesis of novel nucleoside-based prodrugs and antiviral agents.
• Bioconjugation and Probe Development: Utilized for creating labeled nucleic acid probes for diagnostic and research purposes due to its reactive amino group.
• Academic and Industrial Research: Employed in studies exploring nucleic acid structure, function, and the development of new genetic tools.

Basic Information

Product Name	3'--Amino-2',3'-Dideoxy-5'-o-Methoxytrityl-5-Methyluridine
CAS No.	204688-08-4
Molecular Formula	C31H33N3O6
Molecular Weight	543.61 g/mol
Synonyms	5'-O-(4-Methoxytrityl)-3'-amino-2',3'-dideoxy-5-methyluridine; 3'-Amino-2',3'-dideoxy-5'-O-(4-methoxytrityl)-5-methyluridine; 5-Methyl-3'-amino-2',3'-dideoxy-5'-O-MMTr-uridine; MMTr-AmdU; 3'-Amino-5-methyl-2',3'-dideoxyuridine 5'-(4-methoxytrityl) ether; 204688-08-4; 5'-O-MMT-3'-amino-2',3'-dd-5-methylU
EINECS	Contact for details

Quality Control

Our 3'--Amino-2',3'-Dideoxy-5'-o-Methoxytrityl-5-Methyluridine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive pharmaceutical research. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.