Description

Nε-Palmitoyl-L-Glutamic Acid γ-Succinimidyl-α-tert-Butyl Ester is a high-purity, bifunctional chemical building block designed for advanced bioconjugation and peptide synthesis. This compound is critical for researchers and manufacturers requiring precise, site-specific modification of biomolecules, particularly in the development of novel therapeutic agents and diagnostic tools. It is primarily utilized by pharmaceutical R&D teams, biotech companies, and fine chemical suppliers focused on creating peptide-drug conjugates, vaccines, and targeted delivery systems.

Application

• Peptide-Drug Conjugate (PDC) Synthesis: Serves as a key linker for covalently attaching cytotoxic drugs or imaging agents to targeting peptides.
• Antigen/Adjuvant Conjugation: Used in vaccine development to couple antigens with immunostimulatory molecules or carrier proteins.
• Protein and Antibody Modification: Enables site-specific labeling of proteins and antibodies with fluorophores, biotin, or other functional probes for diagnostics.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a protected, activated intermediate for the controlled introduction of palmitoyl (lipid) groups onto peptides.
• Lipidated Peptide Production: Essential for synthesizing lipopeptides that mimic natural post-translational modifications, used in metabolic and signaling studies.
• Prodrug Development: Employed to create prodrugs with enhanced solubility, stability, or targeted release profiles.
• Biomaterial Functionalization: Used to graft bioactive peptides onto polymer surfaces or nanoparticles for tissue engineering and drug delivery applications.

Basic Information

Product Name	Nε-Palmitoyl-L-Glutamic Acid γ-Succinimidyl-α-tert-Butyl Ester
CAS No.	204521-63-1
Molecular Formula	C29H50N2O7
Molecular Weight	538.73 g/mol
Synonyms	Nε-Palmitoyl-L-glutamic acid γ-succinimidyl α-tert-butyl ester; Nα-Boc-Nε-palmitoyl-L-glutamic acid N-succinimidyl ester; Palmitoyl-Glu(OSu)-OtBu; Boc-Glu(Pal)-OSu; L-Glutamic acid, N-(1-oxohexadecyl)-, 5-[(2,5-dioxo-1-pyrrolidinyl) ester], 1-(1,1-dimethylethyl) ester; N-Palmitoyl-glutamic acid α-t-butyl ester γ-OSu; 204521-63-1; Lipopeptide building block
EINECS	Contact for details

Quality Control

Our Nε-Palmitoyl-L-Glutamic Acid γ-Succinimidyl-α-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. We provide Certificates of Analysis (COA) with detailed specifications for trace solvents, moisture content (KF), and related substances. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term stability, store under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	[α]D20: Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.