Description

Azt (Methyl-13C, 99%) 96% Chemical Purity is a stable isotope-labeled analog of the nucleoside reverse transcriptase inhibitor, Zidovudine (AZT). This compound is essential for advanced pharmacokinetic and metabolic studies, providing a critical internal standard for precise quantitative analysis. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug metabolism and mass spectrometry-based bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard for the accurate quantification of Zidovudine and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables precise tracking of the parent drug's absorption, distribution, metabolism, and excretion (ADME) profile in preclinical and clinical research.
• Mass Spectrometry Method Development: Used to validate and optimize sensitive and specific bioanalytical assays, improving accuracy and reproducibility.
• Isotope Dilution Mass Spectrometry (IDMS): Applied in high-precision analytical techniques for absolute quantification, ensuring superior data integrity in regulatory submissions.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometric analysis.
• Stable Isotope Labeling Studies: Facilitates research into metabolic pathways and enzymatic mechanisms without radioactive hazards.

Basic Information

Product Name	Azt (Methyl-13C, 99%) 96% Chemical Purity
CAS No.	202114-48-5
Molecular Formula	C10H1313CN5O4
Molecular Weight	268.68 g/mol (for 13C1 labeled form)
Synonyms	Zidovudine (Methyl-13C); AZT (Methyl-13C); 3'-Azido-3'-deoxythymidine (Methyl-13C); Azidothymidine (Methyl-13C); BW A509U (Methyl-13C); Retrovir (Methyl-13C); 1-((2R,4S,5S)-4-Azido-5-((13C)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Every batch of Azt (Methyl-13C, 99%) is produced and analyzed under strict quality management protocols. The product undergoes rigorous testing, including NMR and mass spectrometry, to confirm isotopic enrichment (13C, 99%) and chemical purity (96%). A comprehensive Certificate of Analysis (COA) detailing assay, isotopic purity, and impurity profile is provided with each shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product at 2-8°C under inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 96%
Isotopic Enrichment (13C)	≥ 99 atom %
Chemical Purity	≥ 96%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.