Description

Z-Leu-Arg-Betana Hcl CAS NO 202002-15-1 is a specialized synthetic peptide derivative, primarily used as a key intermediate or substrate in advanced biochemical research and pharmaceutical development. This compound is critical for scientists and manufacturers requiring high-purity, well-characterized building blocks for protease studies, drug discovery, and diagnostic reagent formulation. It is essential for research institutions, biotechnology companies, and pharmaceutical developers focused on enzymology, cardiovascular research, and novel therapeutic agent synthesis.

Application

• Biochemical Research: As a specific fluorogenic or chromogenic substrate for studying the activity and kinetics of serine proteases, including thrombin and trypsin-like enzymes.
• Pharmaceutical Development: Serves as a critical intermediate in the synthesis of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Diagnostic Reagents: Used in the formulation of in-vitro diagnostic (IVD) kits for clinical assays measuring coagulation factors and other protease activities.
• Enzyme Characterization: A tool for the identification, inhibition profiling, and functional analysis of proteolytic enzymes in various biological pathways.
• Academic Research: Employed in university and institutional labs for fundamental studies in biochemistry, cell signaling, and disease mechanisms.

Basic Information

Product Name	Z-Leu-Arg-Betana Hcl
CAS No.	202002-15-1
Molecular Formula	C24H38N6O6 • HCl
Molecular Weight	535.06 g/mol (for free base, contact for exact salt form weight)
Synonyms	Benzyloxycarbonyl-Leucyl-Arginine 4-Nitroanilide Hydrochloride; Z-Leu-Arg-pNA • HCl; Z-Leu-Arg-NA • HCl; Nα-CBZ-L-Leucyl-L-arginine 4-nitroanilide hydrochloride; Chromogenic Substrate for Thrombin; Thrombin Substrate I (p-nitroanilide); Boc-Leu-Arg-pNA HCl (common misnomer); CBZ-Leu-Arg-pNA hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Z-Leu-Arg-Betana Hcl is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and performance consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with the standards expected for research-grade and pharmaceutical intermediate materials, ensuring reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Specific Optical Rotation	Contact for details
Biological Activity	Functional activity confirmed in standard enzyme assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.