Description

H-Ala-Pro-Ala-Arg-βna is a synthetic tetrapeptide derivative incorporating a β-naphthylalanine (βna) moiety. This specialized peptide sequence is of significant interest in biochemical and pharmaceutical research, particularly for studying enzyme-substrate interactions and protease activity. It serves as a critical tool compound for researchers and developers in the life sciences sector, enabling advancements in drug discovery and diagnostic assay development.

Application

• Protease Substrate & Enzyme Assays: Used as a selective chromogenic or fluorogenic substrate for studying the kinetics and specificity of serine proteases, including thrombin, trypsin, and related enzymes.
• Biochemical Research Reagent: Employed in fundamental research to investigate peptide hydrolysis mechanisms, enzyme inhibition, and signal transduction pathways.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the discovery and development of novel therapeutic agents targeting proteolytic enzymes.
• Diagnostic Kit Component: Incorporated into in vitro diagnostic (IVD) kits for the detection and quantification of specific protease activities in clinical samples.

Basic Information

Product Name	H-Ala-Pro-Ala-Arg-βna
CAS No.	201985-59-3
Molecular Formula	C30H42N8O6
Molecular Weight	610.71 g/mol
Synonyms	Ala-Pro-Ala-Arg-2-Naphthylalanine; APAR-βNA; H-Ala-Pro-Ala-Arg-2-Nal-OH; Tetrapeptide Substrate APAR-βNA; Thrombin Substrate Analog; L-Alanyl-L-prolyl-L-alanyl-N5-(diaminomethylidene)-L-ornithyl-3-(2-naphthyl)-L-alanine; Protease Substrate 201985-59-3
EINECS	Contact for details

Quality Control

Our H-Ala-Pro-Ala-Arg-βna is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity assessment and MS for identity confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.