Description

Z-Tyr-Lys-Arg-4Mβna is a specialized fluorogenic peptide substrate designed for high-sensitivity enzymatic assays. This compound is critical for researchers and quality control labs requiring precise measurement of protease activity, particularly for enzymes like thrombin or trypsin. It is primarily utilized in pharmaceutical R&D, biochemical research, and diagnostic kit development where accurate, reproducible results are paramount.

Application

• Protease Activity Assays: As a fluorogenic substrate for the kinetic study and quantification of serine proteases, including thrombin, trypsin, and related enzymes.
• Pharmaceutical Research & Development: Used in high-throughput screening (HTS) to identify and characterize novel protease inhibitors for drug discovery programs.
• Diagnostic Development: A key component in the formulation of clinical diagnostic kits for measuring coagulation factors or other protease-related biomarkers.
• Biochemical Research: Employed in enzyme kinetics studies to determine kinetic parameters (Km, Vmax) and elucidate enzymatic mechanisms.
• Quality Control in Biologics: Used to monitor and validate the activity and purity of enzyme-based therapeutics during manufacturing processes.

Basic Information

Product Name	Z-Tyr-Lys-Arg-4Mβna
CAS No.	201983-42-8
Molecular Formula	C37H51N9O9
Molecular Weight	765.87 g/mol
Synonyms	Benzyloxycarbonyl-Tyrosine-Lysine-Arginine-4-Methoxy-β-Naphthylamide; Z-Tyr-Lys-Arg-MNA; Z-Y-K-R-4MβNA; Thrombin Substrate III (fluorogenic); Boc-Tyr-Lys-Arg-4-Methoxy-2-Naphthylamide (common naming variant); Nα-Benzyloxycarbonyl-L-tyrosyl-Nω-[(benzyloxy)carbonyl]-L-lysyl-L-arginine 4-methoxy-2-naphthylamide; Fluorogenic Peptide Substrate for Thrombin/Trypsin
EINECS	Contact for details

Quality Control

Our Z-Tyr-Lys-Arg-4Mβna is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and performance in standard assay conditions. We adhere to relevant guidelines for research-grade biochemicals to support your compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water
Functional Activity	Conforms to reference in standard thrombin/trypsin assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.