Description

H-Thr(Tbu)-Amc Hcl is a protected amino acid derivative widely used as a key building block in peptide synthesis. This compound matters for its role in facilitating complex peptide chain assembly by protecting the threonine side chain, thereby preventing unwanted side reactions. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, APIs, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical intermediate for the controlled, sequential addition of amino acids in automated and manual peptide synthesis.
• Solution-Phase Peptide Synthesis: Used in classical coupling methodologies for constructing specific peptide fragments or smaller sequences.
• Pharmaceutical Research & Development: Serves as a building block for synthesizing peptide-based drug candidates, including hormone analogs, enzyme inhibitors, and diagnostic agents.
• Bioconjugation and Labeling: The protected amine and carboxyl groups allow for selective modification, useful in creating peptide-protein conjugates or fluorescently tagged probes.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Biochemical Research: Fundamental reagent for studying protein structure-function relationships, enzyme mechanisms, and signal transduction pathways.

Basic Information

Product Name	H-Thr(Tbu)-Amc Hcl
CAS No.	201860-40-4
Molecular Formula	C13H25N3O4 • HCl
Molecular Weight	323.82 g/mol (Free base: 287.35)
Synonyms	H-Thr(O-t-Bu)-Amc hydrochloride; L-Threonine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(1,1-dimethylethyl)-, amide, hydrochloride; Fmoc-Thr(tBu)-NH2 • HCl; Fmoc-O-tert-butyl-L-threonine amide hydrochloride; N-α-Fmoc-O-tert-butyl-L-threoninamide hydrochloride; Fmoc-Thr(tBu)-CONH2 • HCl; Protected Fmoc-Threonine amide; tert-Butyl O-[2-[(9H-fluoren-9-ylmethoxy)carbonylamino]-1-(aminocarbonyl)propyl]-L-threoninate hydrochloride
EINECS	Contact for details

Quality Control

Our H-Thr(Tbu)-Amc Hcl is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.