Description

H-D-Ala-Pna . Hcl is a high-purity, protected amino acid derivative used as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise stereochemistry and functional group protection in peptide and peptidomimetic development. It is primarily utilized in pharmaceutical R&D for the synthesis of novel therapeutic agents, as well as in academic research exploring biochemical pathways and structure-activity relationships.

Application

• Pharmaceutical Intermediates: Key building block for the solid-phase and solution-phase synthesis of complex peptides and bioactive molecules.
• Protease Substrate Analogues: Used in the development and study of enzyme inhibitors and substrates for proteolytic enzymes.
• Peptidomimetic Research: Serves as a crucial component in creating stable, drug-like molecules that mimic natural peptides.
• Bioconjugation Chemistry: Employed in the preparation of labeled peptides or peptide-protein conjugates for diagnostic and research applications.
• Academic & Industrial R&D: A valuable reagent for exploring new synthetic methodologies and structure-activity relationships (SAR) in medicinal chemistry.

Basic Information

Product Name	H-D-Ala-Pna . Hcl
CAS No.	201731-77-3
Molecular Formula	C₁₃H₁₈N₄O₃ • HCl
Molecular Weight	314.76 g/mol (Free base: 278.31 g/mol)
Synonyms	H-D-Ala-PNA hydrochloride; D-Alanine-P-nitroanilide hydrochloride; N-(3-(2-Aminopropanamido)phenyl)-4-nitrobenzenesulfonamide hydrochloride; D-Ala-pNA • HCl; H-D-Ala-pNA hydrochloride; Peptide synthesis building block 201731-77-3; Protected D-alanine derivative
EINECS	Contact for details

Quality Control

Our H-D-Ala-Pna . Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms to structure
Identification (IR)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.