Description

Heptadecanoic Acid n-Hydroxysuccinimide Ester is a high-purity, activated fatty acid derivative designed for efficient bioconjugation and labeling applications. This compound serves as a critical reagent for the covalent attachment of the C17 fatty acid chain to primary amine groups on proteins, peptides, and other biomolecules, enabling studies in lipid metabolism, protein modification, and probe development. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require reliable, site-specific modification tools.

Application

• Bioconjugation Reagent: For the covalent coupling of heptadecanoic acid (margaric acid) to antibodies, enzymes, and other proteins via primary amine groups (e.g., lysine residues).
• Probe Synthesis: Used in the preparation of fluorescent, isotopic (e.g., 13C, 2H), or other labeled fatty acid probes for metabolic tracing and imaging studies.
• Lipidomics Research: A key intermediate for synthesizing standardized lipids, internal standards, and modified lipids for mass spectrometry-based lipid analysis.
• Surface Functionalization: Employed to create lipid-coated or fatty acid-functionalized surfaces for biosensor development, microarray platforms, and material science applications.
• Pharmaceutical Intermediate: Acts as a building block in the synthesis of more complex lipid-drug conjugates or prodrugs aimed at improving drug delivery and bioavailability.
• Biomaterial Modification: Facilitates the introduction of hydrophobic alkyl chains onto polymers or nanoparticles to alter their biocompatibility and interaction with biological systems.

Basic Information

Product Name	Heptadecanoic Acid n-Hydroxysuccinimide Ester
CAS No.	201472-73-3
Molecular Formula	C21H37NO4
Molecular Weight	367.53 g/mol
Synonyms	Heptadecanoic Acid NHS Ester; Margaric Acid N-Hydroxysuccinimide Ester; 1-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-1-oxoheptadecane; NSC 334368; Heptadecanoyloxy-2,5-pyrrolidinedione; C17:0 Fatty Acid NHS Ester; n-Heptadecanoic Acid Succinimidyl Ester; Heptadecanoic Acid, 2,5-dioxo-1-pyrrolidinyl ester
EINECS	Contact for details

Quality Control

Our Heptadecanoic Acid n-Hydroxysuccinimide Ester is manufactured under strict quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. We support compliance with relevant quality frameworks for laboratory and non-GMP manufacturing use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant (e.g., in a sealed bag with silica gel) due to its hygroscopic and moisture-sensitive nature. For long-term storage, keep under an inert atmosphere (argon or nitrogen) to prevent hydrolysis of the active ester. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile; slightly soluble in chloroform

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.