Description

1,2-Diphytanoyl-Sn-Glycero-3-Phosphoethanolamine is a synthetic, chemically defined phospholipid featuring branched phytanoyl chains, which confer exceptional stability against oxidation and hydrolysis. This engineered lipid is critical for creating robust, long-lasting lipid bilayers that mimic biological membranes under demanding experimental conditions. It is an essential component for researchers and manufacturers in structural biology, drug delivery system development, and advanced biosensor fabrication, where membrane integrity and reproducibility are paramount.

Application

• Liposome and Nanoparticle Formulation: A key building block for creating highly stable, non-lamellar or fusogenic liposomes used in targeted drug delivery and vaccine adjuvants.
• Membrane Protein Research: Essential for solubilizing, stabilizing, and crystallizing transmembrane proteins (e.g., GPCRs, ion channels) due to its ability to form stable bicelles and lipidic cubic phases.
• Artificial Membrane Systems: Used in the construction of solid-supported lipid bilayers (SLBs) and tethered bilayer lipid membranes (tBLMs) for biophysical studies and biosensor platforms.
• Model Membrane Studies: Provides a defined, oxidation-resistant lipid environment for studying lipid raft dynamics, phase separation, and membrane fusion processes.
• Diagnostic Assay Development: Incorporated into lipid coatings for microarrays and lateral flow assays to reduce non-specific binding and improve signal-to-noise ratios.
• Cosmetic & Dermal Formulations: Employed in high-end cosmetic products as a biomimetic emulsifier and skin barrier repair agent.

Basic Information

Product Name	1,2-Diphytanoyl-Sn-Glycero-3-Phosphoethanolamine
CAS No.	201036-16-0
Molecular Formula	C49H98NO8P
Molecular Weight	860.28 g/mol
Synonyms	DPhyPE; 1,2-Diphytanoylphosphatidylethanolamine; DPhyPE Lipid; PE(3Me-16:0/3Me-16:0); 1,2-Di(3,7,11,15-tetramethylhexadecanoyl)-sn-glycero-3-phosphoethanolamine; Diphytanoyl PE; Avanti Polar Lipids Catalog # 850366; Branched-chain Phosphatidylethanolamine
EINECS	Contact for details

Quality Control

Every batch of 1,2-Diphytanoyl-Sn-Glycero-3-Phosphoethanolamine is produced and analyzed under strict quality management systems. We employ advanced analytical techniques including NMR, HPLC, and mass spectrometry to verify chemical identity, purity, and lipid composition. Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with your research or GMP-grade manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98% (Area %)
Solvent Residue (GC)	Meet ICH guidelines
Water Content (KF)	≤ 1.0 %
Phase Transition Temperature	Contact for details
Bacterial Endotoxins	< 10 EU/mg (for injectable grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.