Description

Triapine is a synthetic small molecule and a potent inhibitor of ribonucleotide reductase (RR), a key enzyme in DNA synthesis and cell proliferation. This targeted mechanism of action makes it a compound of significant interest for advanced research and development. It is primarily utilized by pharmaceutical researchers and developers in the fields of oncology and biochemistry. The product is supplied under the identifier Triapine CAS NO 200933-27-3 to ensure precise sourcing and traceability.

Application

• Oncology Research: Investigated as a potential chemotherapeutic agent for various cancers, including leukemia and solid tumors, due to its ability to halt DNA synthesis in rapidly dividing cells.
• Biochemical Pathway Studies: Used as a specific tool compound to study the role and inhibition of ribonucleotide reductase in cellular metabolism and nucleotide metabolism pathways.
• Drug Discovery & Development: Serves as a lead compound or reference standard in the discovery of novel anti-cancer therapeutics targeting nucleotide metabolism.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate efficacy, pharmacokinetics, and mechanism of action.
• Combination Therapy Research: Studied in conjunction with other chemotherapeutic agents or radiation to assess synergistic effects and overcome drug resistance.
• Academic Research: Utilized in university and institutional labs for fundamental research in cell biology, molecular pharmacology, and cancer biology.

Basic Information

Product Name	Triapine
CAS No.	200933-27-3
Molecular Formula	C10H12N4OS
Molecular Weight	236.30 g/mol
Synonyms	3-Aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP; OCX-191; PAN-811; NSC 663249; 3-Aminopyridine-2-carboxaldehyde thiosemicarbazone; 2-Pyridinecarboxaldehyde, 3-amino-, 2-(4,5-dihydro-2-thiazolyl)hydrazone
EINECS	Contact for details

Quality Control

Our Triapine is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.