Description

Triiodothyronine Glucuronide is a key conjugated metabolite of the thyroid hormone triiodothyronine (T3). This compound is of significant importance in endocrinology and pharmaceutical research for studying hormone metabolism, detoxification pathways, and pharmacokinetics. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers focused on thyroid function, metabolic disorders, and analytical method development.

Application

• Biomedical Research Standard: Serves as a critical reference standard and calibrator in analytical methods (LC-MS, HPLC) for quantifying thyroid hormone metabolites in biological samples.
• Endocrine Pathway Studies: Used to investigate the glucuronidation pathway, phase II metabolism, and the inactivation and excretion mechanisms of thyroid hormones.
• Pharmaceutical Development: Employed in drug metabolism and pharmacokinetic (DMPK) studies for compounds that may interact with or affect thyroid hormone pathways.
• Diagnostic Assay Development: Essential raw material for the production and calibration of immunoassays and test kits designed to measure thyroid hormone metabolites.
• Toxicology & Safety Assessment: Applied in studies assessing the impact of environmental or pharmaceutical agents on thyroid hormone homeostasis and metabolic fate.

Basic Information

Product Name	Triiodothyronine Glucuronide
CAS No.	29919-72-0
Molecular Formula	C24H27I3NO10
Molecular Weight	862.09 g/mol
Synonyms	T3 Glucuronide; 3,3',5-Triiodothyronine Glucuronide; Liothyronine Glucuronide; Triiodothyronine O-Glucuronide; T3G; Glucuronosyl Triiodothyronine; (2S,3S,4S,5R,6S)-6-[[(4S)-4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]amino]-3,4,5-trihydroxyoxane-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Triiodothyronine Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, keep desiccated under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.