Description

Dimethyl Suberimidate is a bifunctional crosslinking agent belonging to the imidoester class, primarily used for protein conjugation and structural studies. This compound is valued for its ability to form stable covalent bonds between primary amines under mild, physiological conditions, preserving the native charge of the target molecules. It is an essential reagent for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and structural biology, where precise and reversible crosslinking is required.

Application

• Protein-Protein Crosslinking: For studying protein interactions, complexes, and quaternary structure in structural biology.
• Antibody Modification & ADC Linker Chemistry: As a cleavable linker or spacer arm in the synthesis of antibody-drug conjugates and other targeted therapeutics.
• Membrane Protein Stabilization: Used to fix and stabilize membrane protein complexes for electron microscopy (e.g., Cryo-EM) and X-ray crystallography.
• Affinity Chromatography Ligand Immobilization: For covalently attaching proteins, antibodies, or other ligands to solid supports like agarose or sepharose beads.
• Cell Surface Labeling: For tagging cell surface proteins and receptors while maintaining cell viability, useful in flow cytometry and imaging.
• Fixative for Electron Microscopy: As part of a fixation protocol to preserve ultrastructural details in biological samples.
• Peptide & Oligonucleotide Conjugation: Enabling the site-specific attachment of peptides, tags, or oligonucleotides to carrier proteins.
• Material Science & Polymer Chemistry: Serving as a crosslinker for amine-functionalized polymers, hydrogels, and nanomaterials.

Basic Information

Item	Details
Product Name	Dimethyl Suberimidate
CAS No.	29878-26-0
Molecular Formula	C10H20N2O2
Molecular Weight	200.28 g/mol
Synonyms	Dimethyl Suberimidate; Suberimidic Acid, Dimethyl Ester; Dimethyl Octanedimidate; DMS; Bis(methyl) Suberimidate; NSC 112192; Octanedioic Acid Bis(methylimidate); 1,8-Dimethyl Suberimidate
EINECS	Contact for details

Quality Control

Our Dimethyl Suberimidate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for life science research and biopharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under desiccant or inert atmosphere to prevent hydrolysis and maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in water, methanol, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.