Description

Pth-L-Proline CAS NO 29635-99-2 is a protected derivative of the amino acid L-proline, where the amine group is shielded by a phthaloyl (Pth) protecting group. This modification is critical in peptide synthesis, preventing unwanted side reactions and enabling the selective formation of peptide bonds. It is an essential building block for research chemists and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of complex peptides.
• Solution-Phase Peptide Synthesis: Used in traditional coupling reactions for producing specific peptide sequences.
• Pharmaceutical Research & Development: Serves as a crucial reagent in the discovery and development of new peptide drugs and APIs.
• Bioconjugation: Facilitates the site-specific attachment of peptides to other molecules, such as proteins, polymers, or dyes.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening of bioactive peptide compounds.
• Academic & Industrial Research: A fundamental tool for studying peptide structure, function, and metabolism.

Basic Information

Product Name	Pth-L-Proline
CAS No.	29635-99-2
Molecular Formula	C₁₃H₁₁NO₄
Molecular Weight	245.23 g/mol
Synonyms	N-Phthaloyl-L-proline; (S)-1-(1,3-Dioxoisoindolin-2-yl)pyrrolidine-2-carboxylic acid; L-Proline, N-phthaloyl-; Phthaloyl-L-proline; N-Pth-L-proline; 2-Pyrrolidinecarboxylic acid, 1-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (S)-; Fmoc compatible Pth-Pro-OH
EINECS	Contact for details

Quality Control

Our Pth-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, optical rotation for chiral integrity, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-80° to -90° (c=1 in DMF)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.