Description

Phenylthiohydantoin Aspartic Acid (CAS NO 29588-04-3) is a specialized derivative of aspartic acid, a key amino acid, modified with a phenylthiohydantoin moiety. This compound is of significant value in advanced biochemical research and analytical chemistry, particularly for peptide and protein sequencing. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in proteomics and amino acid analysis.

Application

• Edman Degradation Reagent: Used as a key intermediate or derivative in the stepwise degradation of peptides for N-terminal amino acid sequencing.
• Proteomics Research: Serves as a reference standard or analytical tool in the study of protein structure, function, and post-translational modifications.
• Amino Acid Analysis: Employed in chromatographic methods (HPLC, LC-MS) for the identification and quantification of aspartic acid derivatives.
• Biochemical Synthesis: Acts as a building block or protected intermediate in the synthesis of more complex peptides or peptide mimetics.
• Pharmaceutical Development: Utilized in the research phase for developing peptide-based therapeutics and diagnostic agents.
• Quality Control Standards: Functions as a high-purity certified reference material (CRM) for calibrating analytical instruments in QC labs.

Basic Information

Product Name	Phenylthiohydantoin Aspartic Acid
CAS No.	29588-04-3
Molecular Formula	C₁₃H₁₄N₂O₃S
Molecular Weight	278.33 g/mol
Synonyms	PTH-Aspartic Acid; PTH-Asp; 3-[(Phenylamino)(thioxo)methyl]-2-aminosuccinic Acid; Aspartic Acid Phenylthiohydantoin; (2S)-2-Amino-3-[(phenylcarbamothioyl)amino]butanedioic Acid; Edman Degradation Product of Asp; N-Phenylthiocarbamoyl-Aspartic Acid
EINECS	Contact for details

Quality Control

Our Phenylthiohydantoin Aspartic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.