Description

12-Doxylstearic Acid is a spin-labeled derivative of stearic acid, incorporating a stable nitroxide radical (doxyl group) at the 12th carbon position. This compound is a vital tool in biophysical and materials research, serving as a paramagnetic probe for studying membrane dynamics, protein-lipid interactions, and molecular order using techniques like Electron Paramagnetic Resonance (EPR) spectroscopy. It is essential for researchers and manufacturers in the fields of biochemistry, pharmaceuticals, and advanced material science who require precise molecular reporters for structural and dynamic analysis.

Application

• Membrane Biophysics Research: As a spin probe for investigating lipid bilayer fluidity, phase transitions, and lateral organization in model and biological membranes via EPR spectroscopy.
• Protein-Lipid Interaction Studies: Used to label lipid molecules to study binding, insertion, and conformational changes of membrane-associated proteins and peptides.
• Polymer Science: Employed as a spin label to analyze molecular mobility, free volume, and compatibility within polymer blends and composites.
• Antioxidant Research: Serves as a model compound in studies of radical scavenging activity and oxidative stress in lipid systems.
• Drug Delivery Systems: Utilized as a tracer to monitor the stability, integrity, and release kinetics from lipid-based nanocarriers like liposomes.
• Material Characterization: Acts as a paramagnetic probe for surface analysis and to study molecular orientation in liquid crystals and ordered soft materials.

Basic Information

Product Name	12-Doxylstearic Acid
CAS No.	29545-47-9
Molecular Formula	C24H46NO3
Molecular Weight	396.63 g/mol
Synonyms	12-DOXYL-stearic acid; 12-(4,4-Dimethyl-3-oxazolidinyloxy)stearic acid; 12-NS; Stearic acid, 12-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl) ester; 12-SASL; 12-SASL spin label; 12-Doxyl methyl stearate derivative; EPR probe 12-doxyl
EINECS	Contact for details

Quality Control

Our 12-Doxylstearic Acid is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and EPR to confirm identity, purity, and radical integrity. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation of the nitroxide radical. Keep the container in a dry, cool, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
EPR Signal	Characteristic triplet spectrum
Melting Point	Contact for details
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.