Description

3-((3-Bromoacetylpyridinio)Propyl)Adenosine Pyrophosphate CAS NO 29486-87-1 is a specialized nucleotide derivative, designed as a potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP) enzymes. This compound is a critical biochemical tool for researchers investigating DNA repair mechanisms, cellular stress responses, and the pathways of programmed cell death (apoptosis). It is primarily utilized in life science research, pharmaceutical development, and as a reference standard in analytical laboratories.

Application

• Biochemical Research: A key reagent for studying PARP enzyme kinetics, inhibition, and its role in DNA damage repair pathways.
• Pharmaceutical Development: Used in high-throughput screening (HTS) and lead optimization for novel oncology and neurology therapeutics targeting PARP.
• Cell Biology Studies: Employed to induce and study PARP-mediated cellular processes, including apoptosis and necrosis, in various cell lines.
• Diagnostic Assay Development: Serves as a critical component in developing enzymatic assays for PARP activity and inhibitor screening kits.
• Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, and NMR for quality control and method validation.

Basic Information

Product Name	3-((3-Bromoacetylpyridinio)Propyl)Adenosine Pyrophosphate
CAS No.	29486-87-1
Molecular Formula	C20H25BrN6O12P2
Molecular Weight	683.29 g/mol
Synonyms	3-Bromoacetylpyridine Adenine Dinucleotide Phosphate; 3-Br-Acetylpyridine-NAD+; 3-BAP-NAD+; 3-(3-Bromoacetylpyridinio)propyl-ADP-ribose; PARP Inhibitor I; 3-AB-PP; NAD+ analog, bromoacetylpyridine derivative; 3-Bromoacetylpyridine adenine dinucleotide phosphate
EINECS	Contact for details

Quality Control

Our 3-((3-Bromoacetylpyridinio)Propyl)Adenosine Pyrophosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.