Description

Narciclasine is a naturally occurring isocarbostyril alkaloid with potent biological activity, derived from plants of the Amaryllidaceae family. This compound is of significant interest for its unique mechanism of action, primarily as a protein synthesis inhibitor. It serves as a valuable reference standard and active pharmaceutical ingredient (API) for researchers and developers in the life sciences sector, particularly for investigating novel therapeutic pathways.

Application

• Pharmaceutical Research & Development: As a reference standard in analytical method development and validation for quality control of related drug substances.
• Anticancer Agent Studies: Used in preclinical research to study its potent antiproliferative and apoptosis-inducing effects against various cancer cell lines.
• Neurobiological Research: Investigated for its potential neurotrophic and neuroprotective properties in models of neurological disorders.
• Plant Physiology & Biochemistry: Serves as a tool compound to study plant defense mechanisms and secondary metabolite biosynthesis.
• Bioassay Development: Employed as a positive control in assays screening for protein synthesis inhibition or cytotoxic activity.
• Academic & Contract Research: A key material for universities and CROs conducting fundamental research in medicinal chemistry and pharmacology.

Basic Information

Product Name	Narciclasine
CAS No.	29477-83-6
Molecular Formula	C₁₄H₁₃NO₇
Molecular Weight	307.26 g/mol
Synonyms	Narciclasine; Lycoricidinol; 7-Deoxy-trans-dihydronarciclasine; Amaryllidaceae Alkaloid; NSC 196473; 1,2,4,5,12,12b-Hexahydro-7,9,10-trihydroxy-3-methoxy-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-one
EINECS	Contact for details

Quality Control

Our Narciclasine is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.