Description

Z-Arg(No2)-Pna is a specialized nitroarginine derivative peptide, widely utilized as a key intermediate and research chemical. This compound is critical for biochemical research and pharmaceutical development, particularly in the study of nitric oxide synthase (NOS) inhibition and related enzymatic pathways. It serves the needs of research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in peptide synthesis and signal transduction research.

Application

• Nitric Oxide Synthase (NOS) Research: Acts as a substrate analog and inhibitor in enzymatic studies to investigate the nitric oxide pathway.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of more complex peptide-based drug candidates and bioactive molecules.
• Biochemical Assay Development: Used in the development and calibration of high-throughput screening assays for enzyme activity and inhibitor discovery.
• Protease Substrate: Functions as a chromogenic or fluorogenic substrate for studying the activity of specific proteases like trypsin and related enzymes.
• Academic & Industrial R&D: Employed in basic research to understand cardiovascular, neurological, and immunological processes modulated by arginine derivatives.
• Reference Standard: Provides a high-purity standard for analytical method development and quality control in peptide manufacturing.

Basic Information

Product Name	Z-Arg(No2)-Pna
CAS No.	29028-60-2
Molecular Formula	C20H22N6O6
Molecular Weight	442.43 g/mol
Synonyms	Z-Arg(NO2)-p-nitroanilide; Nα-Carbobenzoxy-Nω-nitro-L-arginine 4-nitroanilide; Z-Nω-Nitro-L-arginine 4-nitroanilide; Benzyl N-[(2S)-5-[(diaminomethylidene)amino]-1-(4-nitrophenylamino)-1-oxopentan-2-yl]carbamate; CBZ-Nω-Nitro-L-arginine p-nitroanilide; Z-L-Arg(NO2)-pNA; Chromogenic substrate for trypsin; Nα-Cbz-Nω-nitro-L-arginine p-nitroanilide
EINECS	Contact for details

Quality Control

Our Z-Arg(No2)-Pna is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.