Description

2-Ethoxy-4-Fluoro-1-Nitrobenzene is a specialized aromatic nitro compound featuring both ethoxy and fluoro substituents, making it a valuable fluorinated building block in advanced organic synthesis. Its molecular structure is engineered to facilitate selective chemical transformations, particularly in the creation of complex heterocyclic systems and active pharmaceutical ingredients (APIs). This intermediate is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, structurally precise fluorinated synthons.

Application

• Pharmaceutical Intermediate: A key fluorinated precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides where the introduction of fluorine enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Dye & Pigment Manufacturing: Employed in the synthesis of specialized fluorinated dyes and colorants with unique spectral properties.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures.
• Academic & Industrial R&D: A valuable reagent for methodological development and exploring new fluorination pathways in organic chemistry.

Basic Information

Product Name	2-Ethoxy-4-Fluoro-1-Nitrobenzene
CAS No.	28987-44-2
Molecular Formula	C8H8FNO3
Molecular Weight	185.15 g/mol
Synonyms	4-Fluoro-2-ethoxy-1-nitrobenzene; 1-Ethoxy-2-fluoro-4-nitrobenzene; 2-Fluoro-4-nitroanisole; 2-Ethoxy-4-fluoronitrobenzene; Benzene, 2-ethoxy-4-fluoro-1-nitro-; 4-Fluoro-2-ethoxynitrobenzene; 1-Nitro-2-ethoxy-4-fluorobenzene
EINECS	Contact for details

Quality Control

Every batch of 2-Ethoxy-4-Fluoro-1-Nitrobenzene is manufactured and tested under strict quality management systems to ensure consistency and reliability for industrial applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for purity, identity, and impurity profiles to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.