Description

Rac-Normetanephrine-β-o-Glucuronide CAS NO 28932-87-8 is a high-purity biochemical reference standard, specifically the glucuronide conjugate of the catecholamine metabolite normetanephrine. This compound is essential for analytical method development and validation in clinical and pharmaceutical research, ensuring accurate quantification of metabolic pathways. It is primarily used by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in neuroendocrine research, metabolomics studies, and the development of assays for catecholamine metabolites.

Application

• Biochemical Reference Standard: Serves as a primary standard for calibrating analytical instruments like HPLC-MS/MS and LC-MS in quantitative bioanalysis.
• Clinical Diagnostics: Critical for the development and validation of diagnostic assays measuring normetanephrine and its metabolites in urine or plasma, aiding in the diagnosis of pheochromocytoma and paraganglioma.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to investigate the glucuronidation pathways of sympathomimetic drugs and related compounds.
• Metabolomics Research: A key analyte in studies focusing on catecholamine metabolism, stress response, and neuroendocrine system function.
• Quality Control: Employed in the internal quality control processes of diagnostic laboratories and in-house assay validation to ensure result accuracy and reproducibility.

Basic Information

Product Name	Rac-Normetanephrine-β-o-Glucuronide
CAS No.	28932-87-8
Molecular Formula	C17H25NO9
Molecular Weight	387.38 g/mol
Synonyms	Normetanephrine Glucuronide; Normetanephrine-β-D-Glucuronide; (±)-Normetanephrine-β-D-Glucuronide; DL-Normetanephrine-β-D-Glucuronide; 4-Hydroxy-3-methoxy-α-[(methylamino)methyl]benzyl alcohol β-D-glucopyranosiduronic acid; 3-Methoxy-4-hydroxy-α-[(methylamino)methyl]benzyl alcohol β-D-glucopyranosiduronic acid; NMN-Glucuronide
EINECS	Contact for details

Quality Control

Every batch of Rac-Normetanephrine-β-o-Glucuronide is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC and MS, to ensure high purity and batch-to-batch consistency suitable for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, desiccate and keep frozen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.