Description

16-Hydroxydehydroepiandrosterone Sulfate is a significant sulfated metabolite of the adrenal steroid hormone DHEA, playing a crucial role in steroidogenesis and endocrine research. Its value lies in its utility as a key reference standard and intermediate for the development of diagnostic assays and research into steroid metabolism pathways. This compound is essential for pharmaceutical R&D laboratories, clinical diagnostics manufacturers, and academic institutions focused on endocrinology and metabolic disease studies.

Application

• Pharmaceutical Reference Standard: Primary use as a high-purity certified reference material (CRM) for the quantitative analysis of steroid metabolites in biological samples via LC-MS/MS or immunoassay calibration.
• Diagnostic Kit Development: Critical raw material for manufacturing in-vitro diagnostic (IVD) test kits designed to measure adrenal function and related endocrine disorders.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate sulfatase and sulfotransferase activities within steroid metabolic pathways.
• Metabolite Profiling: Serves as an analytical standard in metabolomics and clinical chemistry for profiling steroid hormones in serum, plasma, or urine.
• Endocrinology Studies: A vital tool for research into conditions such as adrenal insufficiency, congenital adrenal hyperplasia (CAH), and polycystic ovary syndrome (PCOS).
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in ADME studies to understand the metabolism of synthetic steroid-based pharmaceuticals.

Basic Information

Product Name	16-Hydroxydehydroepiandrosterone Sulfate
CAS No.	28905-55-7
Molecular Formula	C19H28O6S
Molecular Weight	384.49 g/mol
Synonyms	16α-Hydroxy-DHEA Sulfate; 16α-Hydroxydehydroepiandrosterone 3-Sulfate; 3β,16α-Dihydroxyandrost-5-en-17-one 3-Sulfate; 16α-OH-DHEA-S; (3β,16α)-3,16-Dihydroxyandrost-5-en-17-one 3-Sulfate; 16α-Hydroxy-DHEA-S; 16α-Hydroxyandrost-5-ene-3β,17-diol-3-sulfate; 16α-Hydroxydehydroisoandrosterone Sulfate
EINECS	Contact for details

Quality Control

Our 16-Hydroxydehydroepiandrosterone Sulfate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to ensure traceability and compliance with research and diagnostic industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.