Description

Iodoacetic Acid, [1-14C] is a carbon-14 radiolabeled derivative of iodoacetic acid, a potent alkylating agent. This isotopically labeled compound is essential for precise metabolic and biochemical pathway tracing studies, offering researchers a critical tool for investigating reaction mechanisms and protein function. It is primarily utilized by research scientists and pharmaceutical developers in the fields of biochemistry, proteomics, and drug discovery.

Application

• Biochemical Research: As a site-specific alkylating agent for studying enzyme active sites, particularly those involving cysteine residues.
• Metabolic Pathway Analysis: Tracing the metabolic fate of acetic acid derivatives in in vitro and in vivo systems using the carbon-14 label.
• Proteomics & Protein Chemistry: Selective modification of proteins for structural analysis, functional studies, or affinity labeling.
• Mechanistic Studies: Investigating the mechanisms of glycolysis and other biochemical pathways where iodoacetate acts as an inhibitor.
• Pharmaceutical Development: Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies for radiolabeled drug candidates.
• Toxicology Research: Exploring the biochemical basis of toxicity of alkylating agents.

Basic Information

Item	Detail
Product Name	Iodoacetic Acid, [1-14C]
CAS No.	28747-25-3
Molecular Formula	C2H3IO2 * [14C]
Molecular Weight	Contact for details
Synonyms	2-Iodo[1-14C]acetic Acid; [1-14C]Iodoacetic Acid; Monoiodo[1-14C]acetic Acid; Carboxy-14C-monoiodoacetic Acid; Radiolabeled IAA; Carbon-14 Labeled Iodoacetate; Iodo[1-14C]acetate
EINECS	Contact for details

Quality Control

Every batch of Iodoacetic Acid, [1-14C] is manufactured and analyzed under strict quality systems to ensure high chemical and radiochemical purity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing specific activity, radiochemical purity, chemical purity, and solvent composition are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere when possible to maintain stability. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97% (Chemical Purity)
Radiochemical Purity (Radio-HPLC)	≥ 97%
Specific Activity	Contact for details (mCi/mmol)
Solvent (if supplied in solution)	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.