Description

Fumarylacetoacetate CAS NO 28613-33-4 is a key biochemical intermediate, specifically the hydrolytic product of fumarylacetoacetate hydrolase (FAH) in the tyrosine catabolic pathway. Its primary commercial and research significance lies in its critical role as a reference standard and substrate for enzymatic studies, particularly in the investigation of hereditary tyrosinemia type I. This compound is essential for pharmaceutical R&D laboratories, diagnostic kit manufacturers, and academic institutions focused on metabolic disorder research and enzyme kinetics.

Application

• Biochemical Research Standard: Serves as a high-purity reference material for studying the tyrosine degradation pathway.
• Enzymatic Assay Substrate: Used as a specific substrate for fumarylacetoacetate hydrolase (FAH) activity assays in vitro.
• Diagnostic Development: Employed in the development and calibration of diagnostic tests for Hereditary Tyrosinemia Type I (HT1).
• Pharmaceutical Intermediates: Acts as a crucial intermediate in metabolic research for potential therapeutic interventions targeting FAH deficiency.
• Cell Culture & Metabolism Studies: Utilized in cell-based models to investigate metabolic flux and the biochemical consequences of enzyme defects.

Basic Information

Product Name	Fumarylacetoacetate
CAS No.	28613-33-4
Molecular Formula	C8H8O7
Molecular Weight	216.15 g/mol
Synonyms	Fumarylacetoacetic Acid; (2E,4E)-4,6-Dioxooct-2-enedioic Acid; FAH Substrate; 4,6-Dioxo-2-octenedioic Acid; Tyrosine Metabolite Intermediate; FAAS; 2-Butenedioic acid, 2-acetyl-1,4-dioxo- (E,E)-
EINECS	Contact for details

Quality Control

Our Fumarylacetoacetate is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive biochemical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research-grade biochemicals, ensuring reliability for your critical R&D and diagnostic development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under inert atmosphere. The material is hygroscopic and should be kept in a cool, dry place. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.