Description

D-Erythro-Dihydro-D-Sphingosine-1-Phosphate is a key bioactive sphingolipid metabolite and a stable analog of sphingosine-1-phosphate (S1P). This compound is essential for researchers investigating the S1P signaling pathway, which regulates critical cellular processes including proliferation, migration, and immune response. It is primarily utilized in life science research, pharmaceutical development, and as a reference standard in analytical laboratories for method validation and quality control.

Application

• Biochemical Research: A critical tool for studying the S1P receptor (S1PR) signaling cascade, cell survival, and angiogenesis in vitro and in vivo.
• Pharmaceutical R&D: Serves as a reference compound and intermediate in the development of novel therapeutics targeting immune disorders, cancer, and inflammatory diseases.
• Analytical Standard: Used as a high-purity certified reference material (CRM) for the quantification of sphingolipids via HPLC, LC-MS, or other chromatographic techniques.
• Cell Biology Studies: Employed to investigate its role in lymphocyte trafficking, endothelial barrier function, and cardiovascular physiology.
• Enzyme Assays: Acts as a substrate or inhibitor in assays for sphingosine kinases and other enzymes involved in sphingolipid metabolism.

Basic Information

Product Name	D-Erythro-Dihydro-D-Sphingosine-1-Phosphate
CAS No.	28508-07-8
Molecular Formula	C18H40NO5P
Molecular Weight	381.49 g/mol
Synonyms	Dihydro-S1P; D-erythro-Dihydrosphingosine 1-phosphate; (2S,3R)-2-Amino-3-hydroxyoctadecyl dihydrogen phosphate; D-erythro-Sphinganine 1-phosphate; DHS1P; D-erythro-C18-Dihydrosphingosine-1-phosphate; Sphinganine 1-phosphate; D-erythro-Dihydrosphingosine-1-P
EINECS	Contact for details

Quality Control

Our D-Erythro-Dihydro-D-Sphingosine-1-Phosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, identity confirmation (NMR, MS), and residual solvent screening, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) with lot-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.