Description

Guanosine Diphosphate Mannose, [Mannose-1-14C] is a radiolabeled nucleotide sugar derivative essential for metabolic pathway tracing. This compound is a critical tool for researchers investigating glycosylation processes, mannose metabolism, and the biosynthesis of complex carbohydrates and glycoconjugates. It is primarily required by biochemists, pharmaceutical R&D teams, and academic researchers in life sciences for use in enzymatic assays, tracer studies, and metabolic flux analysis.

Application

• Enzymatic Research & Assay Development: Serves as a radiolabeled substrate for studying the activity and kinetics of glycosyltransferases, particularly those involved in mannose transfer.
• Metabolic Pathway Analysis: Used as a tracer to elucidate and quantify metabolic fluxes in the biosynthesis of N-linked and O-linked glycans, glycolipids, and other glycoconjugates.
• Glycobiology & Biochemistry: Essential for in vitro studies of protein glycosylation, cell surface labeling, and the assembly of oligosaccharide chains.
• Pharmaceutical R&D: Employed in drug discovery programs targeting infectious diseases, congenital disorders of glycosylation (CDGs), and cancer metabolism where mannose pathways are implicated.
• Diagnostic Probe Development: Acts as a precursor for synthesizing labeled probes to detect specific glycosyltransferase activity in clinical samples.

Basic Information

Product Name	Guanosine Diphosphate Mannose, [Mannose-1-14C]
CAS No.	28472-26-6
Molecular Formula	C16H25N5O16P2 * (14C labeled)
Molecular Weight	605.34 g/mol (unlabeled)
Synonyms	GDP-[14C]Mannose; Guanosine 5'-(trihydrogen diphosphate), P'→5'-ester with α-D-[1-14C]mannose; [1-14C]GDP-Mannose; α-D-[1-14C]Mannose 1-guanosine diphosphate; GDP-α-D-[1-14C]mannopyranose; Radiolabeled GDP-Mannose; [14C]GDP-Man
EINECS	Contact for details

Quality Control

Every batch of Guanosine Diphosphate Mannose, [Mannose-1-14C] is produced and analyzed under stringent conditions to ensure high radiochemical purity and specific activity. Quality is verified by techniques including HPLC with radiometric detection and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specific activity, radiochemical purity, chemical purity, and solvent composition. Our quality system supports research requiring reproducible and reliable tracer compounds.

Storage

Preserve in a tightly closed container, protected from light. Store frozen at -20°C or below. Due to its hygroscopic (moisture-sensitive) nature, the product should be handled in a dry environment and allowed to equilibrate to room temperature before opening to prevent condensation. For long-term stability, store under inert atmosphere if the vial has been accessed multiple times.

Specification

Item	Specification
Appearance	White to off-white solid or frozen solution
Identification (HPLC, NMR)	Conforms to structure
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 90%
Solvent	Ethanol:Water mixture or as specified
Concentration	1 mCi/mL (Nominal)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.