Description

10-Formyldihydrofolate is a key folate derivative and metabolic intermediate. This compound is essential for research into one-carbon metabolism pathways and the biosynthesis of nucleotides and amino acids. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biochemical, and life science sectors for enzymatic studies, metabolic pathway analysis, and as a reference standard.

Application

• Biochemical Research: Critical intermediate for studying folate-dependent one-carbon transfer reactions and metabolic pathways.
• Enzymology Studies: Used as a substrate or reference compound for investigating enzymes like formyltetrahydrofolate synthetase and other folate-metabolizing enzymes.
• Pharmaceutical Development: Serves as a reference standard in the research and development of antifolate drugs, chemotherapeutic agents, and metabolic modulators.
• Metabolic Pathway Analysis: Employed in cell culture and in vitro systems to trace and quantify metabolic fluxes in nucleotide and amino acid biosynthesis.
• Diagnostic Reagent Manufacturing: Potential use as a component in enzymatic assay kits for clinical diagnostics and research.
• Academic Research: A vital tool for universities and research institutions exploring cellular metabolism, cancer biology, and nutritional science.

Basic Information

Item	Detail
Product Name	10-Formyldihydrofolate
CAS No.	28459-40-7
Molecular Formula	C₂₀H₂₃N₇O₇
Molecular Weight	473.44 g/mol
Synonyms	10-Formyl-7,8-dihydrofolic acid; 10-CHO-DHF; 10-Formyl-7,8-dihydropteroylglutamate; 10-Formyldihydropteroylglutamic acid; 10-Formyl-7,8-dihydrofolate; 10-Formyl-H₂folate; 10-Formyl-7,8-dihydro-L-glutamic acid, N-[4-[[(2-amino-3,4,5,6,7,8-hexahydro-4-oxo-10-formyl-6-pteridinyl)methyl]amino]benzoyl]-; Folate derivative, 10-formyl-7,8-dihydro-
EINECS	Contact for details

Quality Control

Our 10-Formyldihydrofolate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term stability, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC/UV)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in alkaline aqueous solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.