Description

Dehydrosenecionine is a pyrrolizidine alkaloid (PA) derivative of significant interest in biochemical and pharmaceutical research. Its primary value lies in its role as a key reference standard and intermediate for studying the metabolism, toxicity, and potential bioactivity of pyrrolizidine alkaloids. This compound is essential for researchers and quality control laboratories in the pharmaceutical, phytochemical, and toxicology sectors who require high-purity analytical standards.

Application

• Phytochemical Reference Standard: Used as a certified standard for the identification and quantification of pyrrolizidine alkaloids in plant extracts, herbal medicines, and dietary supplements.
• Toxicology Research: Serves as a critical metabolite or model compound in studies investigating the hepatotoxic and genotoxic mechanisms of pyrrolizidine alkaloids.
• Pharmaceutical Impurity Profiling: Employed in the development and validation of analytical methods (e.g., HPLC, LC-MS) to detect and control PA impurities in active pharmaceutical ingredients (APIs) derived from botanical sources.
• Biochemical Studies: Utilized as a substrate or inhibitor in enzymatic studies related to PA biosynthesis or detoxification pathways.
• Quality Control & Assurance: Acts as a system suitability standard in laboratories ensuring the safety and compliance of natural products and raw materials.

Basic Information

Product Name	Dehydrosenecionine
CAS No.	28379-63-7
Molecular Formula	C18H25NO6
Molecular Weight	351.40 g/mol
Synonyms	Dehydrosenecionine; 12,18-Didehydrosenecionan-11,16-dione, 13,19-Didehydro-12-hydroxy- (8CI); (13Z)-Senecionan-11,16-dione, 12,18-didehydro-12-hydroxy-; 12-Hydroxysenecionan-11,16-dione, 12,18-didehydro-; Dehydro-senecionine; A metabolite of pyrrolizidine alkaloids.
EINECS	Contact for details

Quality Control

Our Dehydrosenecionine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research and analytical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant guidelines for reference standard materials to support your compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities	≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.