Description

2-Mercaptopurine is a sulfur-containing purine analog that serves as a critical active pharmaceutical ingredient (API) and a versatile biochemical building block. Its primary commercial value lies in its potent antimetabolite and immunosuppressive properties, making it essential for therapeutic development and advanced research. This compound is in high demand within the pharmaceutical industry for oncology applications and by research institutions studying cell proliferation and immunology. We supply high-purity 2-Mercaptopurine CAS NO 28128-19-0 to meet the stringent requirements of global manufacturing and scientific communities.

Application

• Oncological Pharmaceutical Manufacturing: Key intermediate and active ingredient in the production of chemotherapy medications for treating acute lymphoblastic leukemia (ALL) and other cancers.
• Immunosuppressive Therapy: Used in formulations for managing autoimmune diseases and preventing organ transplant rejection.
• Biochemical Research: Essential tool in life science research for studying purine metabolism, nucleotide synthesis inhibition, and cellular apoptosis pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Antiviral Drug Development: Investigated as a precursor or model compound in the research of antiviral agents.
• Academic & Industrial R&D: Utilized in synthetic chemistry for creating novel purine derivatives with potential biological activity.

Basic Information

Product Name	2-Mercaptopurine
CAS No.	28128-19-0
Molecular Formula	C5H4N4S
Molecular Weight	152.18 g/mol
Synonyms	6-Mercaptopurine; 6-MP; 6-Thiohypoxanthine; 6-Thiopurine; Purine-6-thiol; Leukerin; Mercaleukin; Ismipur; 1,7-Dihydro-6H-purine-6-thione; 6H-Purine-6-thione, 1,7-dihydro-
EINECS	248-889-1

Quality Control

Our 2-Mercaptopurine is manufactured under strict quality management systems. We offer material compliant with pharmaceutical-grade standards, and specifications can be tailored to meet USP, EP, or customer-specific requirements. Every batch undergoes comprehensive analytical testing, including HPLC for assay and purity, and residual solvent analysis. A Certificate of Analysis (COA) documenting identity, purity, and all critical parameters is provided with each shipment to ensure full traceability and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider maintaining the product under an inert atmosphere such as nitrogen or argon to preserve stability.

Specification

Item	Specification
Appearance	Yellow to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.