Description

Polyuridylic Acid (5') Potassium Salt is a synthetic, single-stranded homopolymer of uridine monophosphate, widely utilized as a critical reagent in molecular biology and biochemical research. Its primary value lies in its role as a template for RNA polymerase and reverse transcriptase, making it indispensable for studying nucleic acid synthesis, hybridization, and enzyme kinetics. This high-purity biochemical is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require reliable and consistent nucleic acid polymers for their work.

Application

• Molecular Biology Research: Used as a synthetic mRNA analog and template in transcription assays, RNA polymerase studies, and nucleic acid hybridization experiments.
• Biochemical Assay Development: Serves as a standard or substrate in enzymatic assays for reverse transcriptase, polynucleotide phosphorylase, and other RNA-processing enzymes.
• Virology and Vaccine Research: Employed in studies of viral replication mechanisms and as a component in the development of mRNA-based vaccine platforms and therapeutics.
• Diagnostic Kit Manufacturing: Acts as a key raw material or positive control in the production of diagnostic kits for RNA detection and quantification.
• Pharmaceutical R&D: Utilized in drug discovery research targeting RNA viruses and in the study of oligonucleotide-based drug interactions.
• Academic and Industrial Laboratories: A fundamental reagent for teaching and advanced research in genetics, cell biology, and synthetic biology.

Basic Information

Product Name	Polyuridylic Acid (5') Potassium Salt
CAS No.	28086-43-3
Molecular Formula	(C9H11KN2O9P)n
Molecular Weight	324.26 (monomer) g/mol
Synonyms	Poly(U) Potassium Salt; Polyuridylic Acid Potassium Salt; 5'-Polyuridylic Acid Potassium Salt; Poly(U); Poly rU; Potassium Polyuridylate; Polyuridylic Acid Homopolymer Potassium Salt; Oligouridylic Acid Potassium Salt (for shorter chains)
EINECS	Contact for details

Quality Control

Our Polyuridylic Acid (5') Potassium Salt is manufactured under stringent conditions to ensure the highest standards of purity and biological activity, suitable for sensitive research and production applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as absorbance ratios, chain length, and endotoxin levels. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the rigorous demands of the global biopharmaceutical supply chain.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For laboratory use, store desiccated at 2-8°C after initial opening.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (UV-Vis)	Characteristic absorption spectrum of poly(U)
Purity (A260/A280)	≥ 2.0
Assay (HPLC)	≥ 95% (Polyuridylic Acid content)
Chain Length (n)	Specified range available (e.g., 100-500, 500-2000 nucleotides)
Potassium Content	As per theoretical calculation
Endotoxin	< 10 EU/mg (for cell culture/vaccine grades)
Solubility	Soluble in water and buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.