Description

5'-Tosyl-2'-Deoxy Cytidine is a key nucleoside derivative where the 5'-hydroxyl group is protected by a tosyl moiety. This modification is critical for controlling reactivity in synthetic pathways, making it a valuable building block for researchers and manufacturers. It is primarily utilized in the synthesis of oligonucleotides, modified nucleosides, and as an intermediate in the development of active pharmaceutical ingredients (APIs). This compound is essential for organizations in pharmaceutical R&D, biotechnology, and fine chemical synthesis seeking high-purity intermediates.

Application

• Oligonucleotide Synthesis: Serves as a protected intermediate in the solid-phase and solution-phase synthesis of DNA and RNA analogs.
• Pharmaceutical Intermediate: A crucial precursor in the production of antiviral and anticancer nucleoside-based drugs.
• Biochemical Research: Used in studies involving nucleic acid chemistry, enzyme mechanisms, and as a substrate for nucleoside kinases.
• Prodrug Development: Employed in the design and synthesis of nucleoside prodrugs to enhance bioavailability and targeting.
• Labeled Compound Synthesis: Acts as a starting material for the preparation of isotopically labeled (e.g., 13C, 15N) nucleosides for metabolic tracing.
• Antisense Technology: A building block for creating modified antisense oligonucleotides with tailored properties.

Basic Information

Product Name	5'-Tosyl-2'-Deoxy Cytidine
CAS No.	27999-55-9
Molecular Formula	C17H21N3O6S
Molecular Weight	395.43 g/mol
Synonyms	5'-O-(4-Methylbenzenesulfonyl)-2'-deoxycytidine; 2'-Deoxy-5'-O-tosylcytidine; 5'-Tosyl-deoxycytidine; dCyt-5'-OTs; 1-[(2R,4S,5R)-4-Hydroxy-5-[(4-methylphenyl)sulfonyloxymethyl]oxolan-2-yl]-4-aminopyrimidin-2-one; 2'-Deoxycytidine 5'-(4-methylbenzenesulfonate); Cytidine, 2'-deoxy-, 5'-(p-toluenesulfonate)
EINECS	Contact for details

Quality Control

Our 5'-Tosyl-2'-Deoxy Cytidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.