Description

5'-O-(Dimethoxytrityl)-5-(Propargyloxy)-2'-Deoxyuridine is a high-purity, protected nucleoside derivative essential for oligonucleotide synthesis. This compound serves as a critical building block for the site-specific introduction of functional groups, enabling advanced research and development in nucleic acid chemistry. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on antisense therapeutics, diagnostic probes, and novel bioconjugation strategies.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Bioconjugation & Labeling: The propargyloxy group enables efficient "click chemistry" (CuAAC) for attaching fluorophores, biotin, or other reporter molecules to oligonucleotides.
• Antisense & siRNA Therapeutics: Used in the development of chemically modified oligonucleotides for enhanced stability, specificity, and cellular delivery.
• Diagnostic Probe Development: Facilitates the creation of sensitive and specific probes for PCR, FISH, and microarray applications.
• Structural Studies: Employed in NMR and X-ray crystallography to study nucleic acid structure and interactions.
• Academic & Industrial R&D: A fundamental reagent for exploring novel nucleic acid modifications and their biochemical properties.

Basic Information

Product Name	5'-O-(Dimethoxytrityl)-5-(Propargyloxy)-2'-Deoxyuridine
CAS No.	27999-47-9
Molecular Formula	C30H30N2O7
Molecular Weight	530.57 g/mol
Synonyms	5'-O-DMT-5-Propargyloxy-dU; DMT-dU(Prop); 5-(2-Propyn-1-yloxy)-2'-deoxyuridine, 5'-(4,4'-dimethoxytrityl) ether; 5-Propargyloxy-2'-deoxyuridine 5'-O-(4,4'-dimethoxytrityl) ether; 5-(Propargyloxy)-2'-deoxyuridine, 5'-O-(4,4'-dimethoxytrityl)-; 5'-O-(4,4'-Dimethoxytrityl)-5-(2-propynyloxy)-2'-deoxyuridine; 5'-O-DMT-5-(O-propargyl)-2'-deoxyuridine
EINECS	Contact for details

Quality Control

Our 5'-O-(Dimethoxytrityl)-5-(Propargyloxy)-2'-Deoxyuridine is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive oligonucleotide synthesis. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under anhydrous conditions. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.