Description

Peptidoglycan CAS NO 27814-48-8 is a vital structural heteropolymer found in the cell walls of most bacteria, composed of glycan chains cross-linked by short peptides. This unique biopolymer is essential for research and development in immunology, microbiology, and pharmaceutical sciences. It is a critical reagent for scientists and manufacturers in the biotechnology, vaccine development, and diagnostic industries, serving as a key tool for studying innate immune responses, bacterial physiology, and as a potential adjuvant.

Application

• Immunological Research: Used as a pathogen-associated molecular pattern (PAMP) to stimulate and study innate immune responses via Toll-like receptor 2 (TLR2) and NOD-like receptors (NLRs).
• Vaccine Adjuvant Development: Investigated for its immunostimulatory properties to enhance the efficacy of next-generation vaccines.
• Microbiological Studies: Essential for research on bacterial cell wall synthesis, structure, and the mechanism of action of antibiotics like β-lactams and vancomycin.
• Diagnostic Reagent: Employed in the development of assays and kits for detecting bacterial infections or specific immune activations.
• Biomaterial Research: Explored for potential applications in drug delivery systems and tissue engineering scaffolds due to its biocompatibility and structural properties.
• Enzyme Substrate: Serves as a substrate for studying the activity of lysozyme and other cell wall hydrolases.

Basic Information

Product Name	Peptidoglycan
CAS No.	27814-48-8
Molecular Formula	(C20H37N5O13)n
Molecular Weight	Variable polymer
Synonyms	Murein; Mucopeptide; Glycopeptide; Bacterial Cell Wall Polymer; Peptidoglycan Monomer; GlcNAc-MurNAc-pentapeptide; N-Acetylglucosaminyl-N-acetylmuramyl-pentapeptide; PG
EINECS	Contact for details

Quality Control

Our Peptidoglycan is produced and tested under stringent quality management protocols to ensure batch-to-batch consistency and biological activity. Each lot is characterized for key parameters including purity, endotoxin level, and immunological activity. A comprehensive Certificate of Analysis (COA) detailing specifications and test results is provided with every shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 90% (Peptidoglycan polymer)
Endotoxin Level (LAL)	< 1.0 EU/mg
Biological Activity (Cell-based assay)	Stimulates TLR2-dependent NF-κB activation
Water Content (KF)	< 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.