Description

Pumiliotoxin C CAS NO 27766-71-8 is a potent alkaloid neurotoxin originally isolated from the skin of poison dart frogs (*Dendrobatidae*). This compound is of significant interest in biochemical and pharmacological research due to its specific action on voltage-gated sodium channels. It serves as a critical reference standard and research tool for neuroscientists, toxicologists, and pharmaceutical developers studying neuroactive compounds, ion channel function, and natural product chemistry.

Application

• Neuroscience Research: Used as a selective tool compound to study the modulation and block of voltage-gated sodium channels in neuronal signaling.
• Toxicology Studies: Serves as a reference standard for the identification and quantification of pumiliotoxins in forensic, environmental, and clinical toxicology analyses.
• Pharmacological Probes: Employed in high-throughput screening and assay development to discover novel analgesics, anesthetics, or neuroprotective agents.
• Natural Product Chemistry: Acts as a key analytical standard for the isolation, characterization, and synthesis of complex amphibian alkaloids.
• Biochemical Reference Material: Provides a certified material for calibrating analytical instruments (HPLC, LC-MS) in academic and industrial laboratories.
• Drug Discovery & Development: Used to investigate structure-activity relationships (SAR) for designing new compounds that target ion channels.

Basic Information

Product Name	Pumiliotoxin C
CAS No.	27766-71-8
Molecular Formula	C19H31NO2
Molecular Weight	305.46 g/mol
Synonyms	Pumiliotoxin 251D; PTX 251D; Allopumiliotoxin 267A; 8-Hydroxy-8-methyl-6-(2-methylpentylidene)-1-azaspiro[4.5]decan-2-one; 1-Azaspiro[4.5]decan-2-one, 8-hydroxy-8-methyl-6-(2-methylpentylidene)-; (-)-Pumiliotoxin C; Pumiliotoxin C, (-)-
EINECS	Contact for details

Quality Control

Our Pumiliotoxin C is produced and handled under strict quality control protocols to ensure identity, purity, and stability for research applications. Each batch is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) is provided, detailing purity, assay results, and chromatographic profiles. We adhere to ISO 9001 quality management principles to guarantee batch-to-batch consistency and reliable supply for the global research community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep under inert atmosphere if specified for the specific grade.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 97% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.