Description

4-Hydroxybenzoyl-Coenzyme A is a specialized biochemical intermediate, a coenzyme A thioester derivative of 4-hydroxybenzoic acid. This compound is of significant interest in research focused on metabolic pathways, particularly those involving the biosynthesis of ubiquinone (coenzyme Q) and other polyprenylated benzoquinones. It serves as a critical substrate for studying enzyme kinetics and mechanisms in aromatic compound metabolism. Researchers in biochemistry, enzymology, and pharmaceutical development utilize this high-purity standard to investigate and modulate key biological processes.

Application

• Enzymology Research: Used as a defined substrate for studying the activity and kinetics of enzymes like 4-hydroxybenzoate polyprenyltransferase in ubiquinone biosynthesis pathways.
• Metabolic Pathway Analysis: A key intermediate for in vitro reconstruction and investigation of metabolic routes leading to the production of coenzyme Q and related compounds.
• Pharmaceutical R&D: Employed in target-based screening and mechanism-of-action studies for potential therapeutics aimed at mitochondrial function and energy metabolism.
• Biochemical Standard: Serves as a high-purity reference standard in analytical methods such as HPLC and LC-MS for quantifying metabolic flux.
• Academic Research: Essential tool in university and institutional labs for fundamental research into aromatic acid metabolism and coenzyme A-dependent enzymatic transformations.

Basic Information

Product Name	4-Hydroxybenzoyl-Coenzyme A
CAS No.	27718-41-8
Molecular Formula	C28H42N7O19P3S
Molecular Weight	917.64 g/mol
Synonyms	p-Hydroxybenzoyl-CoA; 4-Hydroxybenzoyl-coenzyme A; Coenzyme A, S-(4-hydroxybenzoyl)-; S-(4-Hydroxybenzoyl)coenzyme A; 4-Hydroxybenzoyl CoA; p-Hydroxybenzoyl Coenzyme A; 4-Hydroxybenzoate-CoA; 4-HB-CoA
EINECS	Contact for details

Quality Control

Our 4-Hydroxybenzoyl-Coenzyme A is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity assay by HPLC and identity confirmation by mass spectrometry. A Certificate of Analysis (COA) detailing all relevant specifications is provided with every shipment, supporting compliance with rigorous research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated under an inert atmosphere. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Biological Activity	Functional as enzyme substrate

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.