Description

3-(2-Iodoacetamido)-Proxyl is a stable nitroxide radical spin label, widely recognized for its utility in electron paramagnetic resonance (EPR) spectroscopy and spin labeling studies. This compound is essential for probing protein structure, dynamics, and conformational changes by covalently attaching to cysteine residues via its iodoacetamide functional group. It is a critical research tool for biochemists, structural biologists, and pharmaceutical scientists working in drug discovery, protein engineering, and biomolecular interaction analysis.

Application

• Protein Spin Labeling: Site-directed covalent attachment to cysteine residues for EPR spectroscopy studies of protein structure and folding.
• Membrane Protein Analysis: Investigation of dynamics and conformational changes in membrane-bound proteins and receptors.
• Biomolecular Interaction Mapping: Used to study protein-protein, protein-nucleic acid, and protein-ligand interactions through distance measurements.
• Oxidative Stress Research: Acts as a spin trap or probe in studies related to free radicals and redox biology.
• Polymer & Material Science: Serving as a radical initiator or a probe for studying polymer chain dynamics and material surfaces.
• Diagnostic Assay Development: Potential use in developing EPR-based biosensors and diagnostic kits.

Basic Information

Product Name	3-(2-Iodoacetamido)-Proxyl
CAS No.	27048-01-7
Molecular Formula	C10H16IN2O2
Molecular Weight	323.15 g/mol
Synonyms	3-(2-Iodoacetamido)-2,2,5,5-tetramethyl-1-pyrrolidinyloxy; 3-(Iodoacetamido)-PROXYL; Iodoacetamide-Proxyl; PROXYL iodoacetamide; 2,2,5,5-Tetramethyl-1-pyrrolidinyloxy-3-carboxamidoethyl iodide; 3-Carbamoyl-2,2,5,5-tetramethyl-1-pyrrolidinyloxy iodoacetamide; 3-(Iodoacetamido)-2,2,5,5-tetramethylpyrrolidine-1-oxyl
EINECS	Contact for details

Quality Control

Our 3-(2-Iodoacetamido)-Proxyl is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability parameters. We support compliance with relevant research and development standards, and specifications can be tailored upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; desiccants are recommended for long-term storage. Keep container tightly sealed under an inert atmosphere when not in use to maintain stability.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
EPR Activity	Conforms
Melting Point	Contact for details
Water Content (KF)	< 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.