Description

(±)-Cherylline CAS NO 26996-80-5 is a synthetic isoquinoline alkaloid of significant interest in pharmaceutical research and development. This compound serves as a crucial building block and reference standard for the synthesis and study of more complex natural products and potential therapeutic agents. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in medicinal chemistry and alkaloid research. The availability of high-purity (±)-Cherylline is essential for ensuring reproducible results in both synthetic pathways and biological evaluations.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of Amaryllidaceae alkaloids and other bioactive molecules.
• Reference Standard: Used as an analytical standard in HPLC, LC-MS, and NMR for method development, validation, and quality control of related compounds.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new therapeutic avenues, particularly in neuroscience and oncology.
• Asymmetric Synthesis: Serves as a model substrate for developing novel catalytic methods and studying stereoselective transformations.
• Natural Product Synthesis: A fundamental scaffold for the total synthesis of complex natural products like lycorine and crinine-type alkaloids.
• Biochemical Tool: Used in pharmacological assays to investigate biological pathways and receptor interactions.

Basic Information

Product Name	(±)-Cherylline
CAS No.	26996-80-5
Molecular Formula	C17H19NO3
Molecular Weight	285.34 g/mol
Synonyms	DL-Cherylline; (±)-4',7-Dimethoxy-5-methyl-1,2,3,4-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquinolin-6-one; 6,7-Dimethoxy-1-(3,4-methylenedioxyphenyl)-3-methyl-1,2,3,4-tetrahydroisoquinoline; Cherylline (racemic); 1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(3,4-methylenedioxyphenyl)-3-methylisoquinoline; UNII-0K2I6Q6Z0I; 0K2I6Q6Z0I
EINECS	Contact for details

Quality Control

Our (±)-Cherylline is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, 1H/13C NMR for structural confirmation, and residual solvent analysis where applicable. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep the container sealed to protect from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.