Description

Isoharringtonine CAS NO 26833-86-3 is a potent alkaloid compound derived from the *Cephalotaxus* genus, known for its significant biological activity. This compound is a key intermediate and reference standard in pharmaceutical research and development, particularly valued for its anti-leukemic properties. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and academic sectors focused on oncology drug discovery and natural product chemistry.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for quality control and method validation in drug development.
• Oncology Research: Serves as a critical biochemical tool for studying apoptosis mechanisms and screening for novel anti-cancer therapeutics.
• Active Pharmaceutical Ingredient (API) Intermediate: Employed in the synthesis and development of chemotherapeutic agents.
• Biochemical Assays: Utilized in in vitro and in vivo studies to investigate its effects on protein synthesis and cell cycle arrest.
• Natural Product Isolation & Analysis: Acts as a marker compound for the standardization and authentication of plant extracts from *Cephalotaxus* species.
• Academic & Institutional Research: Fundamental for pharmacological and phytochemical studies in university and government laboratories.

Basic Information

Product Name	Isoharringtonine
CAS No.	26833-86-3
Molecular Formula	C28H37NO9
Molecular Weight	531.60 g/mol
Synonyms	Isoharringtonine; Cephalotaxine, 4-methyl 2-hydroxy-2-(3-methylbutyl)butanedioate (ester); Harringtonine isomer; NSC 177481; Iso-harringtonine; (+)-Isoharringtonine; Isoharringtonin; Iso-harringtonin
EINECS	Contact for details

Quality Control

Our Isoharringtonine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and pharmaceutical-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.