Description

Rac Fosfomycin-13C3 Benzylamine Salt is a stable isotope-labeled analog of the broad-spectrum antibiotic fosfomycin, where three carbon atoms are replaced with the 13C isotope. This compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in pharmacokinetic, metabolic, and bioanalytical studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on antibiotic research and drug development.

Application

• Quantitative Bioanalysis: Serves as a primary internal standard for the precise LC-MS/MS quantification of fosfomycin in complex biological matrices such as plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Metabolite Identification & Profiling: Used in stable isotope tracing experiments to study the metabolic pathways and degradation products of fosfomycin.
• Method Development & Validation: Critical for developing, optimizing, and validating robust analytical methods in compliance with FDA, EMA, and ICH guidelines.
• Quality Control & Impurity Testing: Supports impurity profiling and assay verification of fosfomycin active pharmaceutical ingredients (APIs) and finished drug products.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Facilitates accurate measurement of drug concentrations in patient samples to guide personalized dosing regimens.

Basic Information

Item	Detail
Product Name	Rac Fosfomycin-13C3 Benzylamine Salt
CAS No.	26772-57-6
Molecular Formula	C13C3H14NO4P • C7H9N
Molecular Weight	Contact for details
Synonyms	(1R,2S)-1,2-Epoxypropylphosphonic Acid-13C3 Benzylamine Salt; (±)-Fosfomycin-13C3 Benzylamine Salt; Phosphomycin-13C3 Benzylamine Salt; Fosfomycin-13C3 Mono(benzylamine) Salt; (3-Methyloxiranyl)phosphonic Acid-13C3 Benzylamine Salt; Antibiotic MK-955-13C3 Benzylamine Salt; FOM-13C3 Benzylamine Salt
EINECS	Contact for details

Quality Control

Our Rac Fosfomycin-13C3 Benzylamine Salt is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity for demanding analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (Atom % 13C), chemical purity by HPLC, and confirmation of structure. We adhere to industry best practices for stable isotope-labeled compounds, ensuring reliability for GLP and GMP-regulated research.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. The container should be allowed to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.