Description

1,7-Dimethylguanine is a purine derivative and a key modified nucleobase of significant interest in biochemical research and pharmaceutical development. This compound matters as a critical intermediate and reference standard for studying nucleic acid modifications, metabolic pathways, and epigenetic regulation. It is primarily needed by research institutions, pharmaceutical companies, and diagnostic manufacturers engaged in advanced life science research, nucleoside analog synthesis, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel nucleoside analogs and antiviral or anticancer drug candidates.
• Biochemical Research: Used as a reference standard and reagent in studies of DNA/RNA methylation, repair mechanisms, and epigenetic markers.
• Diagnostic Development: Acts as a calibrant or component in the development of assays for detecting specific nucleic acid modifications or metabolic disorders.
• Metabolite Studies: Employed in metabolic pathway analysis and as a standard for quantifying purine derivatives in biological samples via HPLC or LC-MS.
• Enzyme Substrate/Inhibitor Studies: Utilized to investigate the activity and specificity of methyltransferases, nucleoside phosphorylases, and other purine-metabolizing enzymes.

Basic Information

Product Name	1,7-Dimethylguanine
CAS No.	26758-00-9
Molecular Formula	C7H9N5O
Molecular Weight	179.18 g/mol
Synonyms	1,7-Dimethyl-1H-purin-6(7H)-one; 1,7-Dimethylguanine; 6-Oxo-1,7-dimethylpurine; 1,7-Dimethyl-6-oxopurine; N1,N7-Dimethylguanine; Guanine, 1,7-dimethyl-; 1,7-Dimethyl-1,7-dihydro-6H-purin-6-one
EINECS	Contact for details

Quality Control

Our 1,7-Dimethylguanine is produced under a strict quality management system to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.