Description

Poly Adenosine Diphosphate Ribose (Poly ADP-ribose) is a biochemically significant polymer involved in critical cellular signaling and repair pathways. This compound is essential for researchers and developers in life sciences, particularly in the study of DNA damage response, chromatin remodeling, and cell death mechanisms. It is a key reagent for pharmaceutical R&D, academic research, and diagnostic assay development targeting poly(ADP-ribose) polymerase (PARP) activity and related biological processes.

Application

• Biochemical Research: Used as a substrate or standard in enzymatic assays to study PARP (Poly(ADP-ribose) polymerase) enzymes and their inhibitors.
• Pharmaceutical Development: Critical for screening and characterizing novel PARP inhibitors, a major class of oncology therapeutics.
• Diagnostic Reagents: Serves as a key component in developing immunoassays and detection kits for PARylation activity and related biomarkers.
• Cell Signaling Studies: Employed to investigate the role of ADP-ribosylation in DNA repair, genomic stability, apoptosis, and inflammation.
• Enzyme Kinetics: Utilized as a defined substrate for determining the kinetic parameters and specificity of ADP-ribosyltransferases and hydrolases.
• Antibody Production & Validation: Acts as an antigen for generating and testing specificity of antibodies against poly(ADP-ribose) chains.

Basic Information

Product Name	Poly Adenosine Diphosphate Ribose
CAS No.	26656-46-2
Molecular Formula	(C15H22N5O14P2)n • (C5H7O4)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly(ADP-ribose); Poly ADP-ribose; pADPr; PAR; Poly(adenosine diphosphate ribose); Adenosine 5'-(trihydrogen diphosphate), 5'-5'-ester with 1,4-dihydro-1-β-D-ribofuranosyl-3,5-bis(phosphooxy)nicotinamide, homopolymer; Poly(ADP-ribosyl) polymer; Nicotinamide adenine dinucleotide polymer
EINECS	Contact for details

Quality Control

Our Poly Adenosine Diphosphate Ribose is produced and handled under stringent quality protocols suitable for research and in-vitro diagnostic use. Each batch is characterized to ensure identity, purity, and functional activity. Certificates of Analysis (COA) detailing specifications such as polymer length distribution, purity, and biological activity are provided to support your critical applications and ensure traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term stability, store desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 90% (Polymer Content)
Water Content (KF)	≤ 5.0 %
Biological Activity	Functional as PARP substrate (Data provided)
Endotoxin (LAL)	< 1.0 EU/mg (if specified for cell-based assays)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.