Description

(2R,5S)-6α,7α-Epoxyaspidofractinine-3β-Carboxylic Acid Methyl Ester is a high-purity, stereochemically defined alkaloid derivative, serving as a critical chiral building block and reference standard in advanced organic synthesis. Its value lies in its complex fused-ring structure and defined stereochemistry, which are essential for producing compounds with specific biological activity. This intermediate is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing novel therapeutics, particularly in the areas of neurological and anti-cancer agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex natural products and potential drug candidates.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new bioactive molecules, especially within the aspidofractinine alkaloid class.
• Academic & Process Chemistry: Serves as a starting material or model compound for developing novel synthetic methodologies and catalytic transformations.
• Biochemical Tool Compound: Utilized in biological assays to investigate specific enzyme interactions or receptor binding mechanisms.

Basic Information

Product Name	(2R,5S)-6α,7α-Epoxyaspidofractinine-3β-Carboxylic Acid Methyl Ester
CAS No.	26619-93-2
Molecular Formula	C21H24N2O3
Molecular Weight	352.43 g/mol
Synonyms	Methyl (2R,5S)-6α,7α-epoxyaspidofractinine-3β-carboxylate; 3β-Carbomethoxyaspidofractinine 6α,7α-epoxide; Aspidofractinine-3β-carboxylic acid, 6α,7α-epoxy-, methyl ester, (2R,5S)-; 6α,7α-Epoxy-3β-methoxycarbonylaspidofractinine; Kopsinine derivative; Kopsia alkaloid intermediate
EINECS	Contact for details

Quality Control

Our (2R,5S)-6α,7α-Epoxyaspidofractinine-3β-Carboxylic Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.