Description

Tetrahydrocortisone 3-(B-D-*Glucuronide) is a key metabolite of the steroid hormone cortisone, formed through the conjugation of tetrahydrocortisone with glucuronic acid. This conjugation significantly enhances the compound's water solubility, which is a critical property for its physiological processing and excretion. It is primarily utilized in pharmaceutical research and development, serving as an important reference standard and analytical tool for metabolic studies, pharmacokinetics, and clinical diagnostics related to adrenal function and steroid metabolism.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quantitative and qualitative analysis of steroid metabolites in research and quality control laboratories.
• Clinical Diagnostics: Essential for calibrating assays and developing methods to measure steroid hormone metabolites in biological fluids (e.g., urine, plasma) for diagnostic purposes.
• Metabolic Pathway Research: A crucial reagent in studying the Phase II metabolism (glucuronidation) of corticosteroids and understanding drug disposition.
• Biochemical Research: Employed in enzymatic studies to investigate the activity of glucuronosyltransferases (UGT enzymes).
• Toxicology Studies: Used to assess the metabolic profiles of synthetic corticosteroids and their potential interactions.

Basic Information

Product Name	Tetrahydrocortisone 3-(B-D-*Glucuronide)
CAS No.	26312-91-4
Molecular Formula	C27H40O12
Molecular Weight	556.60 g/mol
Synonyms	3α,17α,21-Trihydroxy-5β-pregnane-11,20-dione 3-β-D-Glucuronide; THF Glucuronide; Tetrahydrocortisone Glucuronide; 5β-Tetrahydrocortisone 3-Glucuronide; Urocortisone Glucuronide; (3α,5β,17α)-3,17,21-Trihydroxypregnane-11,20-dione 3-β-D-Glucopyranosiduronic Acid; Cortolone Glucuronide
EINECS	Contact for details

Quality Control

Our Tetrahydrocortisone 3-(B-D-*Glucuronide) is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and diagnostic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.