Description

Glycine Ethyl Ester Hydrochloride, [Glycine 1-14C] CAS NO 26005-10-7 is a radiolabeled derivative of the amino acid glycine, where the carbon-14 isotope is specifically incorporated at the 1-position of the glycine moiety. This compound is a critical tool for metabolic and pharmacokinetic studies, enabling researchers to trace the biochemical pathways and fate of glycine and its derivatives in biological systems. It is essential for scientists in pharmaceutical R&D, agrochemical development, and biochemical research who require precise tracking of molecular incorporation and degradation.

Application

• Tracer Studies in Metabolism Research: Used to investigate the biosynthesis and catabolism of proteins, peptides, and other nitrogen-containing compounds.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as a radiolabeled precursor or intermediate in studies to determine the absorption, distribution, metabolism, and excretion (ADME) profiles of new chemical entities.
• Biochemical Pathway Analysis: Employed to elucidate specific enzymatic pathways involving glycine, such as in the synthesis of porphyrins, purines, and glutathione.
• Agrochemical Research: Utilized in studies to understand the mode of action, metabolic fate, and environmental impact of herbicides or plant growth regulators that interact with amino acid metabolism.
• Synthesis of Labeled Compounds: Acts as a key radiolabeled building block for the preparation of more complex peptides, conjugates, or probe molecules for diagnostic and research purposes.

Basic Information

Product Name	Glycine Ethyl Ester Hydrochloride, [Glycine 1-14C]
CAS No.	26005-10-7
Molecular Formula	C₄H₉¹⁴CNO₂·HCl
Molecular Weight	~154.58 (for unlabeled form C₄H₉ClNO₂)
Synonyms	Ethyl Glycinate Hydrochloride (¹⁴C-labeled); 2-Aminoacetic Acid Ethyl Ester Hydrochloride (1-¹⁴C); Glycine Ethyl Ester HCl (1-¹⁴C); Ethyl 2-aminoacetate hydrochloride (1-¹⁴C); Aminoacetic Acid Ethyl Ester Hydrochloride (¹⁴C); H-Gly-OEt·HCl (1-¹⁴C); GlyOEt·HCl (¹⁴C)
EINECS	Contact for details

Quality Control

Every batch of our radiolabeled compounds is produced and analyzed under stringent conditions to ensure high chemical and radiochemical purity, specific activity, and stability. Quality is verified via techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, specific activity (mCi/mmol or GBq/mmol), radiochemical identity, and solvent composition. Our quality system supports research requiring regulatory compliance for non-clinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider conditions recommended for radiolabeled compounds to minimize radiolytic decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR/NMR)	Conforms to structure
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (for solutions)	Specified on COA (e.g., Ethanol, Water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.