Description

Coproporphyrin I Tetramethyl Ester is a chemically modified porphyrin derivative, specifically the tetramethyl ester of Coproporphyrin I. This compound serves as a crucial intermediate and reference standard in the study of heme biosynthesis and porphyrin metabolism. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostic, and life science research sectors for applications ranging from biochemical assays to the development of photodynamic therapy agents.

Application

• Biochemical Research: Used as a key intermediate and reference standard in studies of heme biosynthesis pathways and porphyrin-related disorders.
• Diagnostic Reagent Manufacturing: Serves as a critical component in the production of calibrators and controls for diagnostic kits measuring porphyrin levels in biological samples.
• Pharmaceutical Development: Investigated as a precursor or active pharmaceutical ingredient (API) intermediate in the research of photodynamic therapy (PDT) agents for cancer treatment.
• Analytical Chemistry: Employed as a high-purity standard for HPLC, LC-MS, and other chromatographic methods to quantify porphyrins in complex matrices.
• Enzyme Activity Studies: Utilized as a substrate or inhibitor in assays for enzymes like coproporphyrinogen oxidase.
• Educational & Reference Material: Supplied to academic and commercial laboratories for use as a teaching tool and certified reference material (CRM).

Basic Information

Product Name	Coproporphyrin I Tetramethyl Ester
CAS No.	25767-20-8
Molecular Formula	C₄₀H₄₆N₄O₈
Molecular Weight	710.82 g/mol
Synonyms	Coproporphyrin I tetramethyl ester; 3,8,13,18-Tetramethyl-21H,23H-porphine-2,7,12,17-tetrapropanoic acid tetramethyl ester; Coproporphyrin I 1,3,5,8-tetramethyl ester; 2,7,12,17-Tetrakis(2-methoxy-2-oxoethyl)-3,8,13,18-tetramethylporphyrin; Copro I tetramethyl ester; Coproporphyrin I TME; COP I TME
EINECS	Contact for details

Quality Control

Our Coproporphyrin I Tetramethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (UV-Vis, MS). We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing batch-specific results. For research and diagnostic applications requiring traceability, we support compliance with relevant ISO and GMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, keep the container in a desiccator to minimize exposure to moisture. Allow the product to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	Dark red to purple crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (UV-Vis)	Spectrum matches reference
Purity (HPLC)	≥ 95% (Area %)
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Soluble in DMSO, DMF, Chloroform; Slightly soluble in Methanol
Loss on Drying	≤ 2.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.