Description

n-[4-[[1-(2,4-Diamino-6-Pteridinyl)Ethyl]Methylamino]Benzoyl]-L-Glutamic Acid is a high-purity, synthetic folate analog of significant importance in biochemical and pharmaceutical research. This compound is valued for its precise chemical structure, which makes it a critical reference standard and a key intermediate in the development of targeted therapeutic agents. It is primarily sought by research institutions, diagnostic manufacturers, and pharmaceutical companies engaged in metabolic studies, assay development, and the synthesis of novel drug candidates.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for quality control and analytical method validation in drug manufacturing.
• Biochemical Research: Used as a precise tool in enzymatic studies, folate metabolism pathway analysis, and receptor binding assays.
• Diagnostic Reagent Intermediate: A key building block in the synthesis of reagents for clinical diagnostic kits, particularly those measuring folate levels or related biomarkers.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed as a high-purity intermediate in the multi-step synthesis of specialized therapeutic compounds.
• Academic & Institutional Research: Utilized in universities and research labs for fundamental studies in chemistry, biology, and medicinal chemistry.

Basic Information

Product Name	n-[4-[[1-(2,4-Diamino-6-Pteridinyl)Ethyl]Methylamino]Benzoyl]-L-Glutamic Acid
CAS No.	25663-23-4
Molecular Formula	C₂₀H₂₅N₉O₅
Molecular Weight	471.47 g/mol
Synonyms	4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl-L-glutamic acid; N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid; Methotrexate impurity; Folate analog; L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-; PT523; NSC 113927
EINECS	Contact for details

Quality Control

Our n-[4-[[1-(2,4-Diamino-6-Pteridinyl)Ethyl]Methylamino]Benzoyl]-L-Glutamic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets stringent specifications for research and pharmaceutical use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.